Impact of Long-Term Dietary High Fat and Eicosapentaenoic Acid on Behavior and Hypothalamic-Pituitary-Adrenal Axis Activity in Amyloidogenic APPswe/PSEN1dE9 Mice
Abstract
Alzheimer’s disease (AD) alters neurocognitive and emotional function and causes dysregulation of multiple homeostatic processes. The leading AD framework pins amyloid beta plaques and tau tangles as primary drivers of dysfunction. However, many additional variables, including diet, stress, sex, age, and pain tolerance, interact in ways that are not fully understood to impact the onset and progression of AD pathophysiology.
Breanna Harris, Ph.D.
Assistant Professor
I am a behavioral endocrinologist studying how organisms physiologically and behaviorally respond to and cope with challenges (stressors).
Latha Ramalingam, Ph.D.
Assistant Professor, Department of Nutrition and Food Studies
Research interests include strategies, both in vitro and in vivo, to investigate the effects of Bioactives (omega-3 fatty acids) in maternal obesity, role of the Renin Angiotensin System (RAS) in beta cells, and the interactions between adipocytes and beta cells and their influence on diabetes and obesity.
Naima Moustaid-Moussa, Ph.D.
Horn Distinguished Professor | Nutritional Sciences & Director | Obesity Research Institute (ORI); Nutritional Sciences
Dr. Moustaid-Moussa’s research has focused on a potential role for adipose tissue in triggering and/or potentiating obesity and associated co-morbidity. Her research has significantly contributed to our understanding of the important role for adipose tissue as an endocrine system that impacts not only fat cell expansion but also whole body homeostasis.