Transcriptomic Analyses of Eicosapen taenoic Acid Effects in Adipose Tissue and Cortex From High Fat Diet-Induced Obese Amyloidogenic Alzheimer Disease Mice

Abstract

Alzheimer’s disease (AD) is specified by amyloid-beta (Aβ) plaques and neuroinflammation. Obesity, marked by excessive white adipose tissue (WAT), leads to metabolic dysfunctions, systemic inflammation and enhances risk for AD. We previously reported that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acids, improved metabolic profiles and reduced serum amyloid β (Aβ40) in diet-induced obese transgenic (TG) amyloidogenic AD mice. Here, we studied the links among obesity, WAT inflammation and neuroinflammation in this AD model.

Naima Moustaid-Moussa, Ph.D.

Horn Distinguished Professor | Nutritional Sciences & Director | Obesity Research Institute (ORI); Nutritional Sciences

Dr. Moustaid-Moussa’s research has focused on a potential role for adipose tissue in triggering and/or potentiating obesity and associated co-morbidity. Her research has significantly contributed to our understanding of the important role for adipose tissue as an endocrine system that impacts not only fat cell expansion but also whole body homeostasis.

Breanna Harris, Ph.D.

Assistant Professor

I am a behavioral endocrinologist studying how organisms physiologically and behaviorally respond to and cope with challenges (stressors).

Latha Ramalingam, Ph.D.

Assistant Professor, Department of Nutrition and Food Studies

Research interests include strategies, both in vitro and in vivo, to investigate the effects of Bioactives (omega-3 fatty acids) in maternal obesity, role of the Renin Angiotensin System (RAS) in beta cells, and the interactions between adipocytes and beta cells and their influence on diabetes and obesity.