Eicosapentaenoic Acid Protects against Metabolic Impairments in the APPswe/PS1dE9 Alzheimer's Disease Mouse Model
Abstract
Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by amyloid-β (Aβ) plaques. Systemic inflammation and obesity may exacerbate AD pathogenesis. We previously reported anti-inflammatory and anti-obesity effects of EPA in mice. We aimed to determine whether EPA reduces obesity-associated metabolic dysfunctions and Aβ accumulation in AD amyloidogenic mice.
Latha Ramalingam, Ph.D.
Assistant Professor, Department of Nutrition and Food Studies
Research interests include strategies, both in vitro and in vivo, to investigate the effects of Bioactives (omega-3 fatty acids) in maternal obesity, role of the Renin Angiotensin System (RAS) in beta cells, and the interactions between adipocytes and beta cells and their influence on diabetes and obesity.
Breanna Harris, Ph.D.
Assistant Professor
I am a behavioral endocrinologist studying how organisms physiologically and behaviorally respond to and cope with challenges (stressors).
Naima Moustaid-Moussa, Ph.D.
Horn Distinguished Professor | Nutritional Sciences & Director | Obesity Research Institute (ORI); Nutritional Sciences
Dr. Moustaid-Moussa’s research has focused on a potential role for adipose tissue in triggering and/or potentiating obesity and associated co-morbidity. Her research has significantly contributed to our understanding of the important role for adipose tissue as an endocrine system that impacts not only fat cell expansion but also whole body homeostasis.