Consistent with glucocorticoid cascade hypothesis, baseline cort increased with age. Overall, tg mice had higher post-stressor, but not baseline, cort than non-tg mice. Across genotypes, females had higher (baseline and post-stressor) cort than males. Tg females had higher Aβ and showed more anxiety-like behavior than tg males. No robust correlations, suggesting outcomes are not related on the individual level.